Low Dose Naltrexone at NCPA 2026: What Clinics Should Know

Low dose naltrexone was on the NCPA stage

Low dose naltrexone came up as one of the emerging compounding trends at the National Community Pharmacists Association's 2026 Annual Convention. In a session titled "How to Turn Emerging Compounding Trends into Practice Opportunities," Sara Hover, RPh, FAARM, senior director of clinical services at PCCA, named LDN among the preparations prescribers are asking pharmacies about. In a follow-up Q&A published by Drug Topics on October 15, she put the weight on pharmacist judgment: reviewing safety data and looking at each patient case by case.

LDN is one of the preparations we make most often, so this post is our practical take for clinics that run an LDN program, or are planning one.

Why LDN reaches a compounding pharmacy at all

Naltrexone is commercially manufactured in a single, much higher strength. Low dose therapy calls for smaller strengths, and nothing is manufactured at those strengths. So each prescription is prepared individually, at exactly the strength written. That makes LDN a patient-specific prescription from the start, and that is the kind of prescription a 503A pharmacy is built to fill.

Our patient page on low dose naltrexone explains this in plain language, and you are welcome to share it with your patients.

What "pharmacist judgment" looks like on an LDN order

The session's point about case-by-case review matches how an LDN prescription moves through our pharmacy:

1. Your provider sends a patient-specific prescription. By direct API connection, e-prescribing or our provider portal. Status comes back to your system as each prescription progresses.
2. A pharmacist reviews the formulation. The strength and the dosage form come from your provider. Our pharmacist checks the formulation before it is made.
3. We prepare the form that fits the strength. LDN is prepared as an oral capsule or a tablet, depending on the strength your provider prescribes.
4. Sensitivities are handled up front. We can leave out dyes, lactose or fillers for patients who are sensitive to them. Our page on dye-free compounded medications covers the details.
5. A team member confirms cost before anything is processed, made, or shipped.
6. We compound and ship. We have a 48-hour compounding time on most preparations. Shipping time is additional and varies by destination.

Three things to settle before an LDN program launches

• The strengths and forms your providers prescribe most. Share them with us during onboarding so we can plan before your first prescriptions arrive. Providers who have not prescribed compounded LDN before can call 423-975-0597 to talk through the strengths and dosage forms we prepare.
• What happens when a strength changes. It happens often with LDN. Send the new prescription and we prepare the new strength to match. A new strength always means a new prescription.
• Refill timing. We fill the number of refills your prescriber approves. Each preparation also carries a beyond-use date on its label. Our explainer on how long a compounded medication lasts is a good one to send to patients.

Many LDN programs sit inside a wider protocol, so we can also prepare LDN alongside your other prescriptions and ship it under your brand, with packaging, labels and your own marketing inserts. Our LDN fulfillment for clinics page lays out the full setup.

Common questions

Is naltrexone a controlled substance?

No. Naltrexone is an opioid antagonist and is not a controlled substance. A prescription from a licensed provider is still required.

What forms do you prepare LDN in?

An oral capsule or a tablet, depending on the strength your provider prescribes. We can leave out dyes, lactose or fillers for patients who are sensitive to them.

Can our providers talk to a pharmacist before prescribing?

Yes. We do not prescribe, but our pharmacists are glad to talk providers through the strengths and dosage forms we prepare. Call 423-975-0597.

Can you ship LDN to patients in every state?

Yes. We are licensed in all 50 states and the District of Columbia, with a resident pharmacy license in Tennessee, where we are based, and a non-resident license in every other state and D.C.

Working with ProCompounding

If you run a virtual care program, our telehealth pharmacy fulfillment page shows how prescriptions move from your platform to the patient's door. When your team is ready, start clinic onboarding and tell us about your LDN program.

This article is general information for clinics and is not medical advice. Compounded preparations are not reviewed or approved by the FDA for safety or efficacy.